Neurokinin Receptor Agonist
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Scyliorhinin I
0 ImagesCat. No.: HY-P10599CAS No.: 103425-21-4Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a Ki value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum.
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GR 64349 acetate
0 ImagesCat. No.: HY-P1278BGR 64349 acetate is a selective neurokinin 2 (NK2) receptor agonist. GR 64349 acetate selectively activates the NK-2 receptor subtype. GR 64349 acetate activates tonic and rhythmic bladder contractions of the micturition reflex. GR 64349 acetate does not inhibit rhythmic bladder contraction activation induced by normal saline. GR 64349 acetate induces inward currents.
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Senktide TFA
0 ImagesCat. No.: HY-W755425Senktide TFA is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50=0.5-3 nM). Senktide TFA less potently agonizes the NK1 receptor (EC50=35 µM). Senktide TFA is promising for research of neurological disease.
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Phyllomedusin
0 ImagesCat. No.: HY-P3092CAS No.: 26145-48-2Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus.
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GR 64349 TFA
0 ImagesCat. No.: HY-P1278AGR 64349 TFA is a selective neurokinin 2 (NK2) receptor agonist. GR 64349 TFA selectively activates the NK-2 receptor subtype. GR 64349 TFA activates tonic and rhythmic bladder contractions of the micturition reflex. GR 64349 TFA does not inhibit rhythmic bladder contraction activation induced by normal saline. GR 64349 TFA induces inward currents.
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Uperolein
0 ImagesCat. No.: HY-P2793CAS No.: 55601-63-3Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles.
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[Nle11]-Substance P
![[Nle11]-Substance P](https://file.medchemexpress.com/product_pic/hy-p1506.gif "Click to View [Nle11]-Substance P Product Detail")
0 ImagesCat. No.: HY-P1506CAS No.: 57462-42-7[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.
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Scyliorhinin II
0 ImagesCat. No.: HY-P1588CAS No.: 112748-19-3Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.
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[Lys5,MeLeu9,Nle10]-NKA(4-10)
![[Lys5,MeLeu9,Nle10]-NKA(4-10)](https://file.medchemexpress.com/product_pic/hy-p1279.gif "Click to View [Lys5,MeLeu9,Nle10]-NKA(4-10) Product Detail")
0 ImagesCat. No.: HY-P1279CAS No.: 137565-28-7[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
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L 363851
0 ImagesCat. No.: HY-125304CAS No.: 100807-53-2L 363851 is a Neurokinin 2 receptor agonist, and induces the contractile response of tracheal smooth muscle devoid of epithelium (IC50 of 3.2 nM) and phosphoinositide hydrolysis (IC50 of 36 μM).
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C14TKL-1
0 ImagesCat. No.: HY-P1379CAS No.: 1423381-12-7C14TKL-1 is a tachykinin-like peptide and exhibits an agonistic activity for neurokinin receptor 1 (NK-1).
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[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)
![[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)](https://file.medchemexpress.com/product_pic/hy-p11075.gif "Click to View [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) Product Detail")
0 ImagesCat. No.: HY-P11075CAS No.: 2770688-04-3[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research.
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[Pro9]-Substance P
![[Pro9]-Substance P](https://file.medchemexpress.com/product_pic/hy-p2475.gif "Click to View [Pro9]-Substance P Product Detail")
0 ImagesCat. No.: HY-P2475CAS No.: 104486-69-3[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM.
![[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA](https://file.medchemexpress.com/product_pic/hy-p1279a.gif "Click to View [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA Product Detail")
![[Asp5,6,Me-Phe8] Substance P (5-11)](https://file.medchemexpress.com/product_pic/hy-p11429.gif "Click to View [Asp5,6,Me-Phe8] Substance P (5-11) Product Detail")
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Tyr0-Neurokinin A
0 ImagesCat. No.: HY-P3848CAS No.: 116868-93-0Tyr0-Neurokinin A is a neuropeptide belongs to tachykinin peptide family. Tyr0-Neurokinin A is an agonist of Tacr2. Tyr0-Neurokinin A can be used in the research of insulin resistance, obesity, diabetes.
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Esmolol
0 ImagesCat. No.: HY-B1392ACAS No.: 81147-92-4Esmolol is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol exerts its antiarrhythmic effect by activating Neurokinin 1 Receptor. Esmolol attenuates post resuscitation myocardial dysfunction. Esmolol improves diabetic wound healing by inhibiting aldose reductase and the production of advanced glycation end products and promoting fibroblast migration. Esmolol can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers.
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Monohydroxy Netupitant-d6
0 ImagesCat. No.: HY-G0012SCAS No.: 2070015-07-3Monohydroxy Netupitant-d6 is the deuterium labeled Monohydroxy Netupitant, which is a metabolite of Netupitant.
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Netupitant metabolite Monohydroxy Netupitant
0 ImagesCat. No.: HY-G0012CAS No.: 910808-12-7Synonyms: Monohydroxy NetupitantMonohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
